Capsule filling using nozzle dosators (ND) has been widely investigated (Jones, 2001; Newton, 2012) and it is one of the main technologies used by pharmaceutical industry today. Nozzles come in sizes that match the diameter of capsules (from 00 to 5), and deliver a specific volume of powder into capsules. However, the amount of powder that the smallest nozzle (size 5) can handle is in the range of 40 mg-80 mg (depending on the density of the powder formulation).

This paper discusses the methodology for the development and scale up of capsule filling operations using a research capsule filling unit (Labby,MG2) and an industrial capsule filling machine (Planeta,MG2).

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Solid Dosage Manufacturing

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Commonly used solid dosage forms include powders, granules, tablets, capsules, pills, films, etc.

CGMP refers to the Current Good Manufacturing Practice regulations enforced by the FDA.

A tablet press is used to compress pharmaceutical powder formulations into tablet form, creating tablets of uniform size, shape and weight.

The crusher industry is still a new industry in China, which belongs to the initial stage of development. However, from the experience of a few decades, the speed is relatively fast, especially the universal crusher. Its application field is expanding continuously, and it is suitable for pharmaceutical, chemical, metallurgical, food, construction and other industries.

Mixing is at the heart of most production systems in the chemical process industry, pharmaceutical industry, food industry, and allied industries. It is of vital importance in processing solids, liquids, and gases in the polymer, glass, ceramics, building materials, pulp and paper, petroleum, and power industries and in industrial waste treatment systems.